Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180812 | 0.84 | TXNRD1 (0.38) | TXNRD1RETRIPK2KDRMAPK14 | |
| SCHEMBL17059460 | 0.74 | RIPK2 (0.48) | RETRIPK2KDRMAPK14PKMYT1 | |
| SCHEMBL17059463 | 0.72 | AOC2 (0.43) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14717972 | 0.72 | RIPK2 (0.66) | RIPK2KDR | |
| SCHEMBL17059467 | 0.71 | RIPK2 (0.36) | RETRIPK2KDRMAPK14PKMYT1 | |
| SCHEMBL17059457 | 0.71 | RIPK1 (0.49) | RETRIPK2KDRMAPK14PKMYT1 | |
| SCHEMBL17059454 | 0.71 | RIPK2 (0.54) | RETRIPK2KDRMAPK14PKMYT1 | |
| SCHEMBL29254180 | 0.68 | TXNRD1 (0.45) | TXNRD1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2595613 | 0.67 | RIPK2 (0.35) | TXNRD1RIPK2KDR | |
| SCHEMBL599817 | 0.62 | LRRK2 (0.44) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |