Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18529850 | 0.88 | TDP1 (0.52) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL14699894 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL1893739 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| Ammonia Solution, Strong SCHEMBL27937320 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL18542613 | 0.83 | TDP1 (0.47) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL4072002 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HSD17B10KDM4EMAPTTSHR | |
| SCHEMBL6924772 | 0.83 | TDP1 (0.51) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL2817995 | 0.83 | TDP1 (0.66) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL6828217 | 0.81 | TDP1 (0.46) | ALDH1A1HSD17B10KDM4ETDP1MAPT | |
| SCHEMBL3539392 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4ETDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116502-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | The Regents Of The University Of Michigan (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138326-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-17 | — | — | WO | disclosed |
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | ALDH1A1 4467/4885HSD17B10 4007/4885KDM4E 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.