Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708888 | 0.75 | SMN1; SMN2 (0.39) | KDM4EALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL14021448 | 0.73 | SMN1; SMN2 (0.38) | KDM4EALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL2581832 | 0.73 | SMN1; SMN2 (0.38) | KDM4EALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL5708919 | 0.73 | SMN1; SMN2 (0.38) | KDM4EALDH1A1GAAL3MBTL1KMT2A | |
| SCHEMBL17064185 | 0.72 | FABP3 (0.33) | — | |
| SCHEMBL17064148 | 0.71 | SMN1; SMN2 (0.35) | KDM4EALDH1A1GAAKMT2AHTT | |
| SCHEMBL9889189 | 0.69 | PTPN1 (0.32) | KDM4EALDH1A1PTPN1ACP1CDC25B | |
| SCHEMBL21081502 | 0.69 | PTPN1 (0.32) | KDM4EALDH1A1PTPN1ACP1CDC25B | |
| SCHEMBL760815 | 0.68 | RAPGEF4 (0.45) | KDM4EALDH1A1GAAMAPTTDP1 | |
| SCHEMBL17064151 | 0.68 | ALDH1A1 (0.54) | KDM4EALDH1A1L3MBTL1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3114117-B1 | IODINE(III)-MEDIATED RADIOFLUORINATION | MASSACHUSETTS GEN HOSPITAL (US) | 2019-10-02 | — | — | EP | disclosed |
| US-9957231-B2 | Iodine(II)-mediated radiofluorination | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-01 | — | — | US | disclosed |
| EP-3114117-A1 | IODINE(III)-MEDIATED RADIOFLUORINATION | The General Hospital Corporation (US) | 2017-01-11 | — | — | EP | disclosed |
| US-20160362375-A1 | Iodine(III)-Mediated Radiofluorination | THE GENERAL HOSPITAL CORPORATION | 2016-12-15 | — | — | US | disclosed |
| US-9434699-B2 | Iodine(III)-mediated radiofluorination | THE GENERAL HOSPITAL CORPORATION (US) | 2016-09-06 | — | — | US | disclosed |
| WO-2015134923-A1 | IODINE(III)-MEDIATED RADIOFLUORINATION | THE GENERAL HOSPITAL CORPORATION (US) | 2015-09-11 | — | — | WO | disclosed |
| US-20150252007-A1 | IODINE(III)-MEDIATED RADIOFLUORINATION | THE GENERAL HOSPITAL CORPORATION | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252007-A1 | IODINE(III)-MEDIATED RADIOFLUORINATION | TPO, FLI1, SSTR3 | KDM4E 1312/4885ALDH1A1 1826/4885GAA 2016/4885 |
| US-20160362375-A1 | Iodine(III)-Mediated Radiofluorination | TPO, FLI1, SSTR3 | KDM4E 1312/4885ALDH1A1 1826/4885GAA 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.