SCHEMBL17065239

SCHEMBL17065239

ONCc1ccc(O)c(O)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 1/20 0.61
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA4 P22748 1/20 0.58
CA6 P23280 1/20 0.58
ALOX15 P16050 3/20 0.54
IGF1R P08069 2/20 0.54
TRPA1 O75762 1/20 0.54
MAPT P10636 4/20 0.52
KDM4E B2RXH2 3/20 0.52
ALDH1A1 P00352 3/20 0.52
ALOX5 P09917 1/20 0.52
GAA P10253 1/20 0.52
BACE1 P56817 1/20 0.52
ERCC1 P07992 3/20 0.52
ERCC4 Q92889 3/20 0.52
ALPL P05186 1/20 0.52
ALPG P10696 1/20 0.52
PLAA Q9Y263 1/20 0.52
TP53 P04637 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL107957 0.83 ARG1 (0.63) ARG1CA1CA2CA4CA6
SCHEMBL6718210 0.82 ARG1 (0.57) ARG1CA1CA2CA4CA6
SCHEMBL8297694 0.81 ARG1 (0.61) ARG1CA1CA2CA4CA6
SCHEMBL2315818 0.80 THRB (0.41) ARG1CA1CA2CA4CA6
SCHEMBL10067934 0.79 ARG1 (0.59) ARG1CA1CA2CA4CA6
SCHEMBL14970857 0.79 ARG1 (0.59) ARG1CA1CA2CA4CA6
SCHEMBL13781413 0.79 MAPT (0.64) ARG1CA1CA2CA4CA6
SCHEMBL30637623 0.77 MAPT (0.68) CA1CA2CA4CA6ALOX15
SCHEMBL735617 0.77 MAPT (0.68) CA1CA2CA4CA6ALOX15
Bromide SCHEMBL15398307 0.77 MAPT (0.62) ARG1CA1CA2CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3161025-B1 POLYMERIC NITRONES AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2019-11-13 EP disclosed
CN-106458871-B Nitrone compounds and their use in personal care 陶氏环球技术有限责任公司 2018-12-28 CN disclosed
US-10064804-B2 Polymeric nitrones and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2018-09-04 US disclosed
EP-3142752-B1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2018-06-20 EP disclosed
EP-3142752-B1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2018-06-20 EP disclosed
US-9828335-B2 Nitrone compounds and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2017-11-28 US disclosed
US-9828335-B2 Nitrone compounds and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2017-11-28 US disclosed
US-9828335-B2 Nitrone compounds and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2017-11-28 US disclosed
US-9796667-B2 Nitrone compounds and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2017-10-24 US disclosed
US-9796667-B2 Nitrone compounds and their use in personal care DOW GLOBAL TECHNOLOGIES LLC (US) 2017-10-24 US disclosed
CN-106458871-A Nitrone compounds and their use in personal care 陶氏环球技术有限责任公司 2017-02-22 CN disclosed
EP-3114110-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE Dow Global Technologies LLC (US) 2017-01-11 EP disclosed
US-20160362361-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC 2016-12-15 US disclosed
US-20160362361-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC 2016-12-15 US disclosed
US-20160362361-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC 2016-12-15 US disclosed
WO-2016003767-A1 POLYMERIC NITRONES AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2016-01-07 WO disclosed
WO-2015175310-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2015-11-19 WO disclosed
WO-2015175310-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2015-11-19 WO disclosed
WO-2015134688-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2015-09-11 WO disclosed
WO-2015134688-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE DOW GLOBAL TECHNOLOGIES LLC (US) 2015-09-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160362361-A1 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE NOX1, NOX5, NOS1 ARG1 7/4885CA1 3990/4885CA2 1301/4885
US-10064804-B2 Polymeric nitrones and their use in personal care NOS1, NOS3, NOX1 ARG1 11/4885CA1 4666/4885CA2 4565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.