Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13141391 | 0.82 | KMT2A (0.35) | LMNACA12CA1CA2CA9 | |
| SCHEMBL4730278 | 0.79 | KMT2A (0.36) | LMNACA12CA1CA2CA9 | |
| SCHEMBL11389305 | 0.76 | FABP4 (0.37) | LMNACA12CA1CA2CA9 | |
| SCHEMBL632529 | 0.76 | KMT2A (0.36) | LMNAALDH1A1KMT2ANPC1KDM4E | |
| SCHEMBL13141386 | 0.72 | CTSS (0.36) | LMNAALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL11389102 | 0.70 | MAPT (0.46) | LMNAALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL28220747 | 0.69 | KMT2A (0.36) | ALDH1A1KMT2ANPC1KDM4ECYP1A2 | |
| SCHEMBL632902 | 0.69 | PKM (0.49) | ALDH1A1MAPTNPC1POLBGAA | |
| SCHEMBL5725289 | 0.67 | POLB (0.46) | LMNACA12CA1CA2CA9 | |
| SCHEMBL23142285 | 0.67 | TDP1 (0.43) | CA12CA1CA2CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149561-B1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC (US) | 2015-09-09 | — | — | EP | disclosed |