Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17068801 | 0.90 | HDAC1 (0.66) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL18477561 | 0.79 | HDAC1 (0.82) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL24211530 | 0.78 | ALDH1A1 (0.57) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL18495059 | 0.78 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL24211717 | 0.78 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL26039905 | 0.76 | ALDH1A1 (0.70) | ALDH1A1GAAKMT2APOLBHTT | |
| SCHEMBL6977299 | 0.74 | HDAC1 (0.57) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL17548489 | 0.73 | ACMSD (1.00) | HDAC1ALDH1A1GAAKMT2AACMSD | |
| SCHEMBL6969616 | 0.73 | HDAC1 (0.55) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL26063924 | 0.73 | HDAC1 (0.56) | HDAC1HDAC6HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | HDAC1 806/4885HDAC6 624/4885HDAC3 718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.