Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 7/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BMI1 | P35226 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708693 | 0.90 | SMN1; SMN2 (0.36) | HPGDSMN1; SMN2GFERRAB9ANPC1 | |
| SCHEMBL1708638 | 0.88 | FFAR1 (0.37) | HPGDSMN1; SMN2GFERNPC1GAA | |
| SCHEMBL1707874 | 0.88 | FFAR1 (0.43) | — | |
| SCHEMBL1708637 | 0.87 | HPGD (0.37) | HPGDSMN1; SMN2GFERRAB9ANPC1 | |
| SCHEMBL1708303 | 0.86 | SMN1; SMN2 (0.37) | HPGDSMN1; SMN2GFERRAB9ANPC1 | |
| SCHEMBL1708070 | 0.83 | LMNA (0.40) | HPGDSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL1708680 | 0.83 | MTNR1A (0.39) | SMN1; SMN2RAB9ANPC1MAPTKMT2A | |
| SCHEMBL1708622 | 0.83 | TSHR (0.35) | HPGDSMN1; SMN2RAB9ANPC1HSD17B10 | |
| SCHEMBL1708180 | 0.82 | SMN1; SMN2 (0.40) | HPGDSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL1708241 | 0.80 | NTRK1 (0.38) | HPGDSMN1; SMN2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |