Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708014 | 0.91 | MAPT (0.35) | MAPTALDH1A1HTTNPSR1FFAR1 | |
| SCHEMBL1708303 | 0.91 | SMN1; SMN2 (0.37) | MAPTALDH1A1HTTCLK1NPSR1 | |
| SCHEMBL10291805 | 0.89 | MTNR1A (0.39) | MTNR1AMTNR1BMAPTALDH1A1HTT | |
| SCHEMBL10292315 | 0.89 | MTNR1A (0.39) | MTNR1AMTNR1BMAPTALDH1A1HTT | |
| SCHEMBL1708151 | 0.88 | FFAR1 (0.40) | MTNR1AMTNR1BMAPTFFAR1NPC1 | |
| SCHEMBL1708678 | 0.88 | FFAR1 (0.46) | MTNR1AMTNR1BFFAR1 | |
| SCHEMBL1708622 | 0.86 | TSHR (0.35) | MAPTALDH1A1HTTNPSR1CD274 | |
| SCHEMBL1708148 | 0.86 | MTNR1A (0.41) | MTNR1AMTNR1BMAPTALDH1A1HTT | |
| SCHEMBL1708693 | 0.85 | SMN1; SMN2 (0.36) | MAPTALDH1A1HTTCLK1NPSR1 | |
| SCHEMBL1707875 | 0.83 | HPGD (0.37) | MAPTALDH1A1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |