Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BMI1 | P35226 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707879 | 0.99 | MAPT (0.34) | MAPTLMNASMN1; SMN2NPSR1BMI1 | |
| SCHEMBL1708268 | 0.92 | SMN1; SMN2 (0.35) | MAPTLMNASMN1; SMN2NPSR1TP53 | |
| SCHEMBL1708264 | 0.91 | ALDH1A1 (0.34) | MAPTINSRIGF1RNTRK1NTRK2 | |
| SCHEMBL1708105 | 0.91 | NTRK1 (0.38) | MAPTLMNASMN1; SMN2NPSR1INSR | |
| SCHEMBL1708250 | 0.91 | ALDH1A1 (0.34) | MAPTINSRIGF1RNTRK1NTRK2 | |
| SCHEMBL1708241 | 0.90 | NTRK1 (0.38) | MAPTLMNASMN1; SMN2NPSR1INSR | |
| SCHEMBL1708392 | 0.88 | INSR (0.32) | INSRIGF1R | |
| SCHEMBL10291340 | 0.88 | MAPT (0.34) | MAPTBMI1TP53NTRK1NPC1 | |
| SCHEMBL3794451 | 0.87 | INSR (0.32) | MAPTINSRIGF1RRAB9A | |
| SCHEMBL10291339 | 0.87 | BMI1 (0.34) | MAPTBMI1TP53NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |