Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708298 | 0.91 | PDE10A (0.33) | MTNR1AMTNR1BMAPTPDE2AALDH1A1 | |
| SCHEMBL1708139 | 0.91 | GFER (0.39) | MTNR1AMTNR1BMAPTSCDGFER | |
| SCHEMBL1708111 | 0.91 | NPC1 (0.33) | MAPTGFERALDH1A1NPSR1KDM4E | |
| SCHEMBL1708680 | 0.86 | MTNR1A (0.39) | MTNR1AMTNR1BMAPTPDE2AALDH1A1 | |
| SCHEMBL1708438 | 0.85 | GFER (0.38) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL1708133 | 0.82 | GFER (0.36) | MAPTSCDGFERALDH1A1KDM4E | |
| SCHEMBL1708637 | 0.82 | HPGD (0.37) | MAPTSCDGFERALDH1A1KDM4E | |
| SCHEMBL10291805 | 0.82 | MTNR1A (0.39) | MTNR1AMTNR1BMAPTSCDGFER | |
| SCHEMBL10292315 | 0.82 | MTNR1A (0.39) | MTNR1AMTNR1BMAPTPDE2AALDH1A1 | |
| SCHEMBL1707997 | 0.82 | PDE2A (0.33) | MAPTPDE2AALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |