Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 6/20 | 0.31 |
| ▸ | TP53 | P04637 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.31 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708026 | 0.91 | BMI1 (0.33) | PDE2AMAPTTP53ALDH1A1NTRK1 | |
| SCHEMBL1708155 | 0.91 | NTRK1 (0.37) | SMN1; SMN2HTTMAPTTP53ALDH1A1 | |
| SCHEMBL1708438 | 0.86 | GFER (0.38) | SMN1; SMN2MAPTTP53ALDH1A1MEN1 | |
| SCHEMBL1708134 | 0.86 | INSR (0.30) | NTRK1NTRK2THRBNPC1RAB9A | |
| SCHEMBL1708250 | 0.85 | ALDH1A1 (0.34) | PDE2AMAPTALDH1A1PKMIDH1 | |
| SCHEMBL1708106 | 0.85 | NPC1 (0.35) | SMN1; SMN2HTTMAPTTP53ALDH1A1 | |
| SCHEMBL1708264 | 0.85 | ALDH1A1 (0.34) | PDE2AMAPTALDH1A1PKMIDH1 | |
| SCHEMBL1708631 | 0.85 | NPC1 (0.35) | SMN1; SMN2HTTMAPTTP53ALDH1A1 | |
| SCHEMBL1708080 | 0.84 | NPC1 (0.35) | PDE2ASMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL1708139 | 0.83 | GFER (0.39) | PDE2ASMN1; SMN2MAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |