Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716544 | 0.83 | HTR2A (0.33) | POLBKDM4ELMNATP53MAPT | |
| SCHEMBL1708342 | 0.81 | NPC1 (0.35) | KDM4EMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1707934 | 0.80 | NPC1 (0.37) | KDM4ELMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL1708593 | 0.79 | TSHR (0.36) | KDM4ELMNATP53MAPTHTT | |
| SCHEMBL1708444 | 0.78 | BRD4 (0.32) | — | |
| SCHEMBL1708436 | 0.78 | P2RX7 (0.30) | — | |
| SCHEMBL1708500 | 0.78 | P2RX7 (0.32) | — | |
| SCHEMBL1707926 | 0.77 | RORC (0.32) | MAPT | |
| SCHEMBL1708601 | 0.77 | NAMPT (0.34) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3717017 | 0.77 | SMN1; SMN2 (0.31) | SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |