Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FSHR | P23945 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17082119 | 1.00 | HCRTR2 (0.33) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL4570186 | 1.00 | HCRTR2 (0.33) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL4570217 | 1.00 | HCRTR2 (0.33) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL17082148 | 0.91 | ROCK2 (0.32) | TSHRFSHRHSD11B1 | |
| SCHEMBL4570221 | 0.91 | ROCK2 (0.32) | TSHRFSHRHSD11B1 | |
| SCHEMBL4570222 | 0.91 | ALDH1A1 (0.35) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL17082195 | 0.91 | ALDH1A1 (0.35) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL17082161 | 0.91 | ALDH1A1 (0.35) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL4570183 | 0.91 | ALDH1A1 (0.35) | HCRTR2HCRTR1PDE5ATSHRFSHR | |
| SCHEMBL17082149 | 0.90 | MAPT (0.33) | HCRTR2HCRTR1PDE5AMALT1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |