Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 13/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708185 | 0.99 | ALDH1A1 (0.37) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL1707930 | 0.94 | MAPT (0.36) | ALDH1A1MAPTMAPK1KDM4EMEN1 | |
| SCHEMBL1707925 | 0.93 | MAPT (0.36) | ALDH1A1MAPTMAPK1KDM4EMEN1 | |
| SCHEMBL1707916 | 0.86 | MTOR (0.36) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL13047337 | 0.84 | FFAR1 (0.37) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL1708183 | 0.84 | FFAR1 (0.39) | MTORPIK3CA | |
| SCHEMBL1708213 | 0.83 | MTOR (0.36) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL10291211 | 0.82 | MTOR (0.34) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL1708348 | 0.81 | GAA (0.39) | ALDH1A1MAPTMAPK1MTORPIK3CA | |
| SCHEMBL3717000 | 0.80 | MAPT (0.34) | ALDH1A1MAPTMAPK1MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |