Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707901 | 0.89 | GAA (0.38) | GAAALOX15KDM4EHSD17B10MAPK1 | |
| SCHEMBL1708346 | 0.85 | FFAR1 (0.43) | GAAALOX15KDM4EHSD17B10MAPK1 | |
| SCHEMBL1707921 | 0.83 | CD274 (0.34) | GAAMAPTCD274 | |
| SCHEMBL1708447 | 0.82 | CD274 (0.33) | GAAMAPTCD274 | |
| SCHEMBL1708185 | 0.82 | ALDH1A1 (0.37) | GAAALOX15KDM4EHSD17B10MAPK1 | |
| SCHEMBL1708215 | 0.81 | ALDH1A1 (0.36) | GAAALOX15KDM4EHSD17B10MAPK1 | |
| Tromethamine SCHEMBL10010628 | 0.81 | FFAR1 (0.40) | GAAKDM4EHSD17B10 | |
| SCHEMBL10010651 | 0.81 | AOC3 (0.35) | GAAALOX15KDM4EHSD17B10MAPK1 | |
| SCHEMBL1708296 | 0.79 | CD274 (0.34) | GAAALOX15HSD17B10ALDH1A1MAPT | |
| SCHEMBL1708301 | 0.78 | SMN1; SMN2 (0.41) | GAAKDM4EALDH1A1MAPTCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |