Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708348 | 0.89 | GAA (0.39) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL1707923 | 0.86 | GAA (0.36) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL1707899 | 0.85 | FFAR1 (0.43) | GAAALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL3719582 | 0.85 | WNT3A (0.39) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL10291552 | 0.84 | MAPT (0.37) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL1708457 | 0.83 | STAT6 (0.37) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL1707869 | 0.83 | STAT6 (0.36) | GAAALDH1A1ALOX15MAPTMAPK1 | |
| SCHEMBL3794470 | 0.79 | RORC (0.33) | GAAALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL1708596 | 0.78 | INSR (0.35) | GAAALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL1708467 | 0.77 | FFAR1 (0.35) | GAAALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |