Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18883345 | 0.91 | TGM2 (0.75) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL17076471 | 0.90 | TGM2 (0.74) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL571878 | 0.88 | TGM2 (0.68) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL17076473 | 0.85 | TGM2 (1.00) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL17076468 | 0.84 | TGM2 (0.72) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL17076474 | 0.82 | TGM2 (0.68) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL29181102 | 0.80 | TGM2 (0.69) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL18711519 | 0.79 | KMT2A (0.71) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL27571758 | 0.79 | KMT2A (0.71) | TGM2KMT2AATMEPHX1EPHX2 | |
| SCHEMBL25531 | 0.79 | KMT2A (0.88) | TGM2KMT2AATMEPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906543-B1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | UNIV ASTON (GB) | 2019-01-02 | — | — | EP | disclosed |
| US-9656978-B2 | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | ASTON UNIVERSITY (GB) | 2017-05-23 | — | — | US | disclosed |
| US-9656978-B2 | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | ASTON UNIVERSITY (GB) | 2017-05-23 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ENPEP, ENPP2, MMP17 | TGM2 4/4885KMT2A 1957/4885ATM 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.