Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708255 | 0.85 | FFAR1 (0.40) | MAPTKDM4ETDP1GPR55L3MBTL1 | |
| SCHEMBL1708640 | 0.85 | FFAR1 (0.46) | FFAR1 | |
| SCHEMBL1708363 | 0.85 | INSR (0.34) | MAPTKDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1708254 | 0.84 | MAPT (0.37) | MAPTKDM4ETDP1GPR55L3MBTL1 | |
| SCHEMBL1708036 | 0.80 | INSR (0.35) | MAPTKDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1708241 | 0.79 | NTRK1 (0.38) | MAPTKDM4ETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1708014 | 0.79 | MAPT (0.35) | MAPTTDP1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL1708105 | 0.79 | NTRK1 (0.38) | MAPTKDM4ETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1708622 | 0.79 | TSHR (0.35) | MAPTKDM4ETDP1GPR55L3MBTL1 | |
| SCHEMBL1708070 | 0.78 | LMNA (0.40) | MAPTKDM4ETDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |