Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708622 | 0.93 | TSHR (0.35) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL1708680 | 0.91 | MTNR1A (0.39) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL1708241 | 0.90 | NTRK1 (0.38) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL1708105 | 0.90 | NTRK1 (0.38) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL3796829 | 0.87 | NTRK1 (0.36) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL1708013 | 0.87 | FFAR1 (0.47) | FFAR1 | |
| SCHEMBL1708113 | 0.86 | FFAR1 (0.40) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL1708111 | 0.85 | NPC1 (0.33) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL1708070 | 0.83 | LMNA (0.40) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL1708284 | 0.83 | MAPT (0.36) | MAPTALDH1A1LMNAMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |