Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708134 | 0.85 | INSR (0.30) | L3MBTL1GAATHRBINSRIGF1R | |
| SCHEMBL1708642 | 0.84 | MAPT (0.35) | MAPTKDM4ETDP1L3MBTL1GPR55 | |
| SCHEMBL1708244 | 0.80 | NPC1 (0.32) | MAPTALDH1A1LMNATSHRINSR | |
| SCHEMBL1708155 | 0.79 | NTRK1 (0.37) | MAPTKDM4ETDP1L3MBTL1GAA | |
| SCHEMBL1708111 | 0.79 | NPC1 (0.33) | MAPTKDM4ETDP1L3MBTL1GPR55 | |
| SCHEMBL1708162 | 0.79 | MAPT (0.34) | MAPTKDM4ETDP1L3MBTL1GPR55 | |
| SCHEMBL1708072 | 0.78 | LMNA (0.37) | MAPTL3MBTL1HPGDGAAALDH1A1 | |
| SCHEMBL1708255 | 0.78 | FFAR1 (0.40) | MAPTKDM4ETDP1L3MBTL1GPR55 | |
| SCHEMBL1708093 | 0.78 | NPC1 (0.38) | MAPTKDM4ETDP1GAAMEN1 | |
| SCHEMBL1708106 | 0.78 | NPC1 (0.35) | MAPTKDM4ETDP1L3MBTL1GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |