Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.31 |
| ▸ | MAPT | P10636 | 7/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.31 |
| ▸ | PKM | P14618 | 5/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707933 | 0.99 | GAA (0.31) | GAAMAPTSMN1; SMN2TP53THRB | |
| SCHEMBL1708287 | 0.90 | MAPT (0.32) | MAPTSMN1; SMN2ALDH1A1MAPK1TSHR | |
| SCHEMBL1708395 | 0.90 | MAPT (0.32) | MAPTSMN1; SMN2ALDH1A1MAPK1TSHR | |
| SCHEMBL1708628 | 0.90 | MAPT (0.32) | MAPTSMN1; SMN2ALDH1A1MAPK1TSHR | |
| SCHEMBL1708091 | 0.89 | ADORA2B (0.31) | MAPTSMN1; SMN2ALDH1A1MAPK1TSHR | |
| SCHEMBL1708715 | 0.88 | RIPK1 (0.32) | — | |
| SCHEMBL1708673 | 0.88 | MAPT (0.33) | MAPTSMN1; SMN2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1708661 | 0.88 | MAPT (0.33) | MAPTSMN1; SMN2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL10009874 | 0.87 | FFAR1 (0.38) | — | |
| SCHEMBL1708358 | 0.87 | L3MBTL1 (0.33) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |