Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17088193 | 0.88 | KMT2A (0.67) | LMNASMN1; SMN2NPC1 | |
| SCHEMBL6201125 | 0.85 | HRH2 (0.61) | SMN1; SMN2CYP2D6NPC1CYP1A2L3MBTL1 | |
| SCHEMBL12188828 | 0.84 | MAPT (0.62) | LMNASMN1; SMN2CYP2D6NPC1CYP1A2 | |
| SCHEMBL12733007 | 0.83 | L3MBTL1 (0.68) | LMNASMN1; SMN2CYP2D6NPC1CYP1A2 | |
| SCHEMBL6280945 | 0.82 | ALDH1A1 (0.56) | LMNASMN1; SMN2NPC1THRBTSHR | |
| SCHEMBL2522956 | 0.81 | NPC1 (0.59) | LMNASMN1; SMN2NPC1CYP1A2CYP2C9 | |
| SCHEMBL7949019 | 0.81 | LMNA (0.54) | LMNASMN1; SMN2STAT3CYP2D6NPC1 | |
| SCHEMBL8371452 | 0.81 | LMNA (0.68) | LMNASMN1; SMN2CYP2D6NPC1CYP3A4 | |
| SCHEMBL2354288 | 0.79 | PLA2G4B (0.60) | LMNASMN1; SMN2CYP2D6CYP1A2THRB | |
| SCHEMBL6282350 | 0.79 | THRA (0.61) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058894-A1 | RADIOLABELED PDE10A LIGANDS | ABBVIE DEUTSCHLAND (DE) | 2016-03-03 | — | — | US | disclosed |
| US-9138494-B2 | Radiolabeled PDE10A ligands | ABBVIE INC. (US) | 2015-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160058894-A1 | RADIOLABELED PDE10A LIGANDS | PDE10A, PDE3A, PDE5A | LMNA 1232/4885SMN1; SMN2 1308/4885STAT3 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.