Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565459 | 1.00 | CRHR1 (0.40) | CRHR1NPY5RGRIA4NPY2RNR3C2 | |
| SCHEMBL17090163 | 0.89 | CRHR1 (0.36) | CRHR1NPY5RGRIA2ALDH1A1ALDH3A1 | |
| SCHEMBL13565594 | 0.89 | CRHR1 (0.36) | CRHR1NPY5RGRIA2ALDH1A1ALDH3A1 | |
| SCHEMBL17090113 | 0.87 | CRHR1 (0.41) | CRHR1NPY5RNPY2RNR3C2ALDH1A1 | |
| SCHEMBL13565260 | 0.87 | CRHR1 (0.41) | CRHR1NPY5RNPY2RNR3C2ALDH1A1 | |
| SCHEMBL13565853 | 0.86 | GRIA4 (0.42) | CRHR1NPY5RGRIA4GRIA2ALDH1A1 | |
| SCHEMBL17090523 | 0.86 | GRIA4 (0.42) | CRHR1NPY5RGRIA4GRIA2ALDH1A1 | |
| SCHEMBL13565136 | 0.86 | CRHR1 (0.44) | CRHR1NPY5RGRIA4GRIA2 | |
| SCHEMBL17090375 | 0.86 | CRHR1 (0.44) | CRHR1NPY5RGRIA4GRIA2 | |
| SCHEMBL13565872 | 0.84 | CRHR1 (0.41) | CRHR1NPY5RGRIA4GRIA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |