Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090508 | 0.85 | MAPT (0.52) | MAPTPOLBPKMHCAR3SMN1; SMN2 | |
| SCHEMBL10113571 | 0.85 | MAPT (0.50) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL13564906 | 0.83 | LMNA (0.39) | MAPTPOLBPKMSMN1; SMN2LMNA | |
| SCHEMBL13565637 | 0.83 | L3MBTL1 (0.41) | MAPTLMNAGAAHTTKMT2A | |
| SCHEMBL11934990 | 0.82 | KAT2B (0.58) | MAPTPOLBPKMHCAR3LMNA | |
| SCHEMBL13564897 | 0.81 | LMNA (0.38) | SMN1; SMN2LMNAMAPK1HTTNPC1 | |
| SCHEMBL11934985 | 0.77 | NPC1 (0.48) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL13565817 | 0.77 | THRB (0.46) | MAPTLMNAHTTKMT2A | |
| SCHEMBL17090137 | 0.77 | MAPT (0.40) | MAPTPOLBPKMHCAR3SMN1; SMN2 | |
| SCHEMBL4983931 | 0.76 | MAPT (0.53) | MAPTPOLBPKMHCAR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |