Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15045664 | 0.79 | LMNA (0.41) | LMNAHTTNPC1TSHRKMT2A | |
| SCHEMBL6494101 | 0.73 | ALDH1A1 (0.41) | LMNAHTTNPC1TSHRGAA | |
| SCHEMBL28142676 | 0.72 | SYK (0.47) | LMNAHTTNPC1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7447537 | 0.72 | ALDH1A1 (0.40) | LMNAHTTNPC1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL7215995 | 0.72 | ALDH1A1 (0.40) | LMNAHTTNPC1TSHRKMT2A | |
| SCHEMBL13606447 | 0.71 | ALDH1A1 (0.40) | LMNAHTTNPC1TSHRKMT2A | |
| SCHEMBL13127917 | 0.71 | HTT (0.46) | LMNAHTTNPC1KMT2AL3MBTL1 | |
| SCHEMBL20533611 | 0.69 | MMP2 (0.42) | PPARGPPARA | |
| SCHEMBL12966146 | 0.68 | LMNA (0.43) | LMNAHTTNPC1KMT2AL3MBTL1 | |
| SCHEMBL7575979 | 0.68 | NAALAD2 (0.47) | GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139569-B2 | Fused tricyclic aryl compounds useful for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2015-09-22 | — | — | US | disclosed |