Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709207 | 0.94 | SCN9A (0.54) | ALDH1A1BACE1SCN9ALMNAAVPR1A | |
| SCHEMBL1709263 | 0.90 | SCN9A (0.53) | ALDH1A1BACE1SCN9ALMNAAVPR1A | |
| SCHEMBL1709268 | 0.87 | SCN9A (0.46) | ALDH1A1BACE1SCN9ALMNAAVPR1A | |
| SCHEMBL1709262 | 0.81 | SCN9A (0.52) | ALDH1A1SCN9AKMT2ADRD4 | |
| SCHEMBL1709219 | 0.81 | SCN9A (0.74) | ALDH1A1SCN9ALMNAKMT2ADRD4 | |
| SCHEMBL10071958 | 0.78 | DRD4 (0.67) | SCN9ADRD4 | |
| SCHEMBL10072167 | 0.76 | SCN9A (0.61) | ALDH1A1SCN9AKMT2ADRD4POLB | |
| SCHEMBL10072168 | 0.76 | SCN9A (0.56) | ALDH1A1SMN1; SMN2SCN9ALMNAKMT2A | |
| SCHEMBL1286815 | 0.76 | KMT2A (0.55) | BACE1SCN9ALMNAKMT2ADRD4 | |
| SCHEMBL1286845 | 0.75 | SCN9A (0.66) | ALDH1A1SCN9ALMNAKMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |