Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709207 | 0.89 | SCN9A (0.54) | SCN9AALDH1A1LMNAKMT2AAVPR1A | |
| SCHEMBL1709274 | 0.87 | ALDH1A1 (0.53) | SCN9AALDH1A1LMNAKMT2AAVPR1A | |
| SCHEMBL1709263 | 0.87 | SCN9A (0.53) | SCN9AALDH1A1LMNAKMT2AAVPR1A | |
| SCHEMBL10072166 | 0.86 | SCN9A (0.60) | SCN9AALDH1A1DRD2DRD3KMT2A | |
| SCHEMBL1709262 | 0.77 | SCN9A (0.52) | SCN9AALDH1A1KMT2ADRD4 | |
| SCHEMBL1709219 | 0.76 | SCN9A (0.74) | SCN9AALDH1A1LMNAKMT2ADRD4 | |
| SCHEMBL1286815 | 0.76 | KMT2A (0.55) | SCN9ALMNAKMT2ABACE1DRD4 | |
| SCHEMBL10072167 | 0.74 | SCN9A (0.61) | SCN9AALDH1A1KMT2ADRD4 | |
| SCHEMBL10071958 | 0.74 | DRD4 (0.67) | SCN9ADRD4 | |
| SCHEMBL10072168 | 0.74 | SCN9A (0.56) | SCN9AALDH1A1LMNAKMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |