Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709314 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2HPGDHSD17B10GAARECQL | |
| SCHEMBL20363289 | 0.87 | KMT2A (0.59) | SMN1; SMN2TSHRHPGDHSD17B10GAA | |
| SCHEMBL20363239 | 0.80 | KMT2A (0.57) | SMN1; SMN2TSHRHPGDHSD17B10GAA | |
| SCHEMBL1709310 | 0.80 | HPGD (0.73) | SMN1; SMN2HPGDHSD17B10GAARAB9A | |
| SCHEMBL4991673 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2HPGDHSD17B10GAARECQL | |
| SCHEMBL179085 | 0.79 | RAB9A (0.76) | SMN1; SMN2HPGDHSD17B10GAARECQL | |
| SCHEMBL30932891 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2HPGDHSD17B10GAARECQL | |
| SCHEMBL2937877 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDHSD17B10GAARECQL | |
| SCHEMBL12863523 | 0.78 | RAB9A (0.60) | SMN1; SMN2GAARAB9AKMT2AMEN1 | |
| SCHEMBL29196210 | 0.78 | HPGD (0.70) | SMN1; SMN2HPGDHSD17B10RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017522-B2 | Alpha helix mimetics and methods relating thereto | Prism BioLab Co., Ltd. (JP) | 2018-07-10 | — | — | US | disclosed |
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PLOD3, COL1A1, THPO | SMN1; SMN2 1774/4885TSHR 3526/4885HPGD 500/4885 |
| US-10017522-B2 | Alpha helix mimetics and methods relating thereto | PLOD3, COL1A1, THPO | SMN1; SMN2 1774/4885TSHR 3526/4885HPGD 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.