Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KDM5C | P41229 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436700 | 0.96 | TSHR (0.50) | TSHRPHF8KDM2AKDM4EKDM5C | |
| SCHEMBL10081169 | 0.89 | TSHR (0.60) | TSHRKDM4EALDH1A1KMT2AHPGD | |
| SCHEMBL18648724 | 0.87 | TSHR (0.58) | TSHRKDM4EALDH1A1KMT2AEPHX2 | |
| SCHEMBL22056519 | 0.81 | TSHR (0.42) | TSHRKDM4EALDH1A1KMT2APKM | |
| SCHEMBL24329788 | 0.79 | TSHR (0.52) | TSHRPHF8KDM2AKDM4EKDM5C | |
| SCHEMBL14241913 | 0.79 | MEN1 (0.56) | TSHRALDH1A1KMT2APKMHPGD | |
| SCHEMBL20048669 | 0.79 | FAAH (0.58) | ALDH1A1HPGDEPHX2 | |
| SCHEMBL18629861 | 0.79 | TSHR (0.43) | TSHRPHF8KDM2AKDM4EKDM5C | |
| SCHEMBL17860027 | 0.78 | KMT2A (0.50) | TSHRALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL6810784 | 0.78 | PHF8 (0.60) | PHF8KDM2AKDM4EKDM5CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | disclosed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088734-A1 | Cyclosporin Analogs | CHP1, TSLP, PPP3R1 | TSHR 3291/4885PHF8 4351/4885KDM2A 4736/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | TSHR 3291/4885PHF8 4351/4885KDM2A 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.