Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857196 | 0.74 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL10882291 | 0.73 | LMNA (0.59) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL23527342 | 0.72 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL5793312 | 0.70 | TDP1 (0.59) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL8804842 | 0.68 | L3MBTL1 (0.55) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL11865755 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL23527323 | 0.66 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL22686835 | 0.65 | TDP1 (0.52) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL22686837 | 0.65 | TDP1 (0.52) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL881068 | 0.64 | ALDH1A1 (1.00) | ALDH1A1KDM4EHSD17B10HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088771-A1 | TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP): A THERAPEUTIC TARGET FOR ARTERIAL CALCIFICATION | Sanford-Burnham Medical Research Institute California | 2012-04-12 | — | — | US | disclosed |