Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17100603 | 0.94 | LMNA (0.35) | NPC1HTTRAB9AMAPK1L3MBTL1 | |
| SCHEMBL17100636 | 0.75 | MAPK1 (0.43) | NPC1HTTRAB9AMAPK1L3MBTL1 | |
| SCHEMBL4084298 | 0.73 | MAPK1 (0.46) | MAPK1TSHRMAPTALDH1A1LMNA | |
| SCHEMBL2316904 | 0.72 | SIGMAR1 (0.47) | HTTMAPK1TSHRALDH1A1LMNA | |
| SCHEMBL5307156 | 0.72 | KMT2A (0.50) | TSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17100743 | 0.71 | ALDH1A1 (0.56) | HTTRAB9AL3MBTL1TDP1MAPT | |
| SCHEMBL217536 | 0.71 | CYP1A2 (0.42) | TSHRLMNASLC6A2SLC6A4 | |
| SCHEMBL12128279 | 0.69 | NPC1 (0.50) | NPC1HTTRAB9AMAPK1L3MBTL1 | |
| SCHEMBL3708454 | 0.69 | CYP1A2 (0.40) | MAPK1TSHRALDH1A1LMNASLC6A2 | |
| SCHEMBL17100749 | 0.69 | L3MBTL1 (0.43) | NPC1HTTRAB9AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119774-A1 | OXADIAZOLE COMPOUNDS | reMynd NV (BE) | 2017-01-25 | — | — | EP | claimed |
| WO-2015140130-A1 | OXADIAZOLE COMPOUNDS | REMYND NV (BE) | 2015-09-24 | — | — | WO | claimed |
| EP-3119774-A1 | OXADIAZOLE COMPOUNDS | reMynd NV (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140130-A1 | OXADIAZOLE COMPOUNDS | REMYND NV (BE) | 2015-09-24 | — | — | WO | disclosed |