Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17100734 | 0.86 | DHODH (0.39) | DHODHKMT2AMEN1MAPT | |
| SCHEMBL17100883 | 0.80 | DHODH (0.42) | DHODHKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17100863 | 0.80 | DHODH (0.35) | DHODHKMT2AKDM4ENPC1MEN1 | |
| SCHEMBL17100903 | 0.78 | DHODH (0.41) | DHODH | |
| SCHEMBL17100800 | 0.78 | NPC1 (0.35) | DHODHKMT2ANPC1MEN1RAB9A | |
| SCHEMBL17100823 | 0.78 | DHODH (0.37) | DHODHKMT2AMEN1MAPT | |
| SCHEMBL17100845 | 0.76 | DHODH (0.36) | DHODHKMT2AMEN1MAPT | |
| SCHEMBL17100690 | 0.76 | PGR (0.35) | DHODHKMT2AKDM4ENPC1MEN1 | |
| SCHEMBL17100731 | 0.75 | DHODH (0.42) | DHODHKMT2AMEN1MAPT | |
| SCHEMBL17100998 | 0.75 | MAPT (0.44) | DHODHKMT2AKDM4ENPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088513-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | ALGIAX PHARMACEUTICALS GMBH (DE) | 2017-03-30 | — | — | US | claimed |
| EP-3119744-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | Algiax Pharmaceuticals GmbH (DE) | 2017-01-25 | — | — | EP | claimed |
| WO-2015140081-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | ALGIAX PHARMACEUTICALS GMBH (DE) | 2015-09-24 | — | — | WO | claimed |
| US-10472324-B2 | 2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives | ALGIAX PHARMACEUTICALS GMBH (DE) | 2019-11-12 | — | — | US | disclosed |
| US-20170088513-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | ALGIAX PHARMACEUTICALS GMBH (DE) | 2017-03-30 | — | — | US | disclosed |
| EP-3119744-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | Algiax Pharmaceuticals GmbH (DE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140081-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | ALGIAX PHARMACEUTICALS GMBH (DE) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088513-A1 | 2-CYANO-3-CYCLOPROPYL-3-HYDROXY-N-ARYL-THIOACRYLAMIDE DERIVATIVES | GABRA3, GABRA2, GABRB3 | DHODH 3129/4885KDM1A 3371/4885PDK2 2718/4885 |
| US-10472324-B2 | 2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives | GABRA3, GABRA2, GABRB3 | DHODH 3129/4885KDM1A 3371/4885PDK2 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.