Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SI | P14410 | 2/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003588 | 0.76 | KDM4E (0.54) | ALDH1A1HSD17B10KDM4EEPHX2HPGD | |
| SCHEMBL102331 | 0.76 | PDPK1 (0.59) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| SCHEMBL28154527 | 0.74 | PDPK1 (0.56) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| SCHEMBL30632310 | 0.74 | PDPK1 (0.56) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| SCHEMBL31556353 | 0.74 | PDPK1 (0.56) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| SCHEMBL30534095 | 0.74 | PDPK1 (0.56) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| SCHEMBL25171037 | 0.70 | KDM4E (0.50) | ALDH1A1HSD17B10KDM4EEPHX2HPGD | |
| SCHEMBL6003629 | 0.69 | ADORA2A (0.46) | ALDH1A1HSD17B10TSHRNOS1HSP90AA1 | |
| Aminothiazole SCHEMBL4962431 | 0.69 | ALDH1A1 (1.00) | ALDH1A1HSD17B10TSHRNOS1KDM4E | |
| Aminothiazole SCHEMBL7401 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279845-B | Aryl or heteroaryl substituted thiadiazoles compounds and antibacterial application thereof | 中国医学科学院药物研究所 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023067515-A1 | THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023067515-A1 | THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| CN-112279845-A | Aryl or heteroaryl substituted thiadiazole compounds and antibacterial application thereof | 中国医学科学院药物研究所 | 2021-01-29 | — | — | CN | disclosed |
| US-20170107212-A1 | NOVEL COMPOUNDS | Bayer Pharma AG (DE) | 2017-04-20 | — | — | US | disclosed |
| US-20170107212-A1 | NOVEL COMPOUNDS | Bayer Pharma AG (DE) | 2017-04-20 | — | — | US | disclosed |
| US-20170107212-A1 | NOVEL COMPOUNDS | Bayer Pharma AG (DE) | 2017-04-20 | — | — | US | disclosed |
| CN-106458983-A | Novel compound | 拜耳制药股份公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-3119759-A1 | NOVEL COMPOUNDS | Bayer Pharma Aktiengesellschaft (DE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140195-A1 | NOVEL COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015140195-A1 | NOVEL COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107212-A1 | NOVEL COMPOUNDS | WNT1, CTNNB1, WNT3A | ALDH1A1 2281/4885HSD17B10 1322/4885TSHR 4575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.