Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102183 | 0.75 | HTR6 (0.47) | LMNAL3MBTL1 | |
| SCHEMBL11327581 | 0.71 | GAA (0.50) | CYP2C9NAMPT | |
| SCHEMBL11831569 | 0.69 | LIPG (0.45) | MAPTCYP2C9NAMPTTP53LMNA | |
| SCHEMBL10890496 | 0.67 | MAPT (0.40) | MAPTLMNA | |
| SCHEMBL10890489 | 0.67 | MAPT (0.40) | MAPTTP53LMNAL3MBTL1 | |
| SCHEMBL11323730 | 0.63 | LMNA (0.40) | MAPTLMNA | |
| SCHEMBL11119676 | 0.60 | HTT (0.50) | MAPTLMNAPOLB | |
| SCHEMBL2069593 | 0.60 | NPC1 (0.56) | MAPTTP53LMNAPOLB | |
| SCHEMBL12083406 | 0.59 | ALDH1A1 (0.59) | MAPTLMNAL3MBTL1 | |
| (Phenylsulfonyl)Benzene SCHEMBL2381369 | 0.59 | HTR6 (0.74) | MAPTLMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119763-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Iteos Therapeutics (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140717-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-09-24 | — | — | WO | disclosed |