Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930775 | 0.87 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL12257766 | 0.85 | KDM4E (0.39) | HSP90AA1HSP90AB1KDM4EHSD17B10KMT2A | |
| SCHEMBL13201505 | 0.83 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL11981453 | 0.82 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL27269634 | 0.79 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL27269606 | 0.79 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL2716163 | 0.78 | CA2 (0.39) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL12553825 | 0.75 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EHTTHSD17B10 | |
| SCHEMBL26022486 | 0.74 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1KDM4EHSD17B10 | |
| SCHEMBL27270718 | 0.73 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | HSP90AA1 2808/4885HSP90AB1 1904/4885KDM4E 3043/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | HSP90AA1 3054/4885HSP90AB1 2254/4885KDM4E 2426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.