Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.73 |
| ▸ | CA2 | P00918 | 3/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15876086 | 0.87 | HIF1A (0.58) | CA1CA2HIF1AALDH1A1MAPT | |
| SCHEMBL28124357 | 0.86 | CA1 (0.69) | CA1CA2HDAC3HDAC1HDAC2 | |
| SCHEMBL17308777 | 0.86 | CA1 (0.80) | CA1CA2HDAC3ALDH1A1MAPT | |
| SCHEMBL1711043 | 0.86 | HDAC1 (0.59) | CA1CA2HDAC1FFAR1HTT | |
| SCHEMBL2190706 | 0.85 | HIF1A (0.55) | CA1CA2FFAR1HIF1AABCG2 | |
| SCHEMBL18415526 | 0.84 | CA1 (1.00) | CA1CA2HDAC3HDAC1HDAC2 | |
| SCHEMBL16355719 | 0.84 | CA1 (0.57) | CA1CA2FFAR1FFAR4HIF1A | |
| SCHEMBL3129145 | 0.84 | ALDH1A1 (0.57) | CA1CA2HTTALDH1A1MAPT | |
| SCHEMBL3291794 | 0.82 | CA1 (0.53) | CA1CA2HDAC3HDAC1HDAC2 | |
| SCHEMBL3129375 | 0.82 | CA1 (0.51) | CA1CA2ABCG2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979510-A | Sulfonamide compounds and their use as STAT5 inhibitors | 多伦多大学管理委员会 | 2021-06-18 | — | — | CN | disclosed |
| EP-3148967-B1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | GOVERNING COUNCIL UNIV TORONTO (CA) | 2019-10-02 | — | — | EP | disclosed |
| EP-3148967-B1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | GOVERNING COUNCIL UNIV TORONTO (CA) | 2019-10-02 | — | — | EP | disclosed |
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| EP-3148967-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | The Governing Council of the University of Toronto (CA) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015179956-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015179956-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
| US-8258138-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |
| US-7714000-B2 | Substituted pyrrolidinones and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-11 | — | — | US | disclosed |
| US-20100087437-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| WO-2010023445-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |
| US-20060217435-A1 | New Substituted Pyrrolidinones and Their Use as Medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087437-A1 | Novel Potassium Channel Blockers | KCNB1, KCNJ2, KCNJ11 | CA1 2149/4885CA2 337/4885HDAC3 448/4885 |
| US-20060217435-A1 | New Substituted Pyrrolidinones and Their Use as Medicaments | PYCR1, S100A9, REV1 | CA1 2387/4885CA2 727/4885HDAC3 4513/4885 |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | STAT5A, STAT5B, JAK2 | CA1 3070/4885CA2 2340/4885HDAC3 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.