Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25844138 | 0.94 | MAPT (0.35) | ALKPDK2ADORA2AADORA1KDM4E | |
| SCHEMBL3155860 | 0.93 | ALDH1A1 (0.33) | PDK2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL1333000 | 0.92 | RAB9A (0.35) | ALKPDK2KDM4EALDH1A1MAPT | |
| SCHEMBL1710974 | 0.92 | RAB9A (0.35) | ALKPDK2KDM4EALDH1A1MAPT | |
| SCHEMBL30914180 | 0.92 | RAB9A (0.35) | ALKPDK2KDM4EALDH1A1MAPT | |
| SCHEMBL25844147 | 0.92 | ALK (0.36) | ALKPDK2ADORA2AADORA1KDM4E | |
| SCHEMBL30658614 | 0.92 | PDK2 (0.35) | PDK2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL21681691 | 0.92 | PDK2 (0.35) | PDK2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL25602404 | 0.91 | ALK (0.45) | ALKKITKDR | |
| SCHEMBL25716067 | 0.91 | PDK2 (0.34) | PDK2KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | claimed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | claimed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | claimed |
| US-7262295-B2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2007-08-28 | — | — | US | claimed |
| US-7166357-B2 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL, INC. (US) | 2007-01-23 | — | — | US | claimed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | claimed |
| US-20040185268-A1 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | claimed |
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2345648-B1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL INC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-2345648-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7557208-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7517982-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-7262295-B2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | disclosed |
| US-7166357-B2 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
| US-20040185268-A1 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | IPO4, NPM1, PPOX | ALK 3416/4885PDK2 3531/4885ADORA2A 2937/4885 |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | IPO5, IPO4, NQO1 | ALK 3220/4885PDK2 2215/4885ADORA2A 2965/4885 |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | IPO5, IPO4, NQO1 | ALK 3220/4885PDK2 2215/4885ADORA2A 2965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.