Sugi Predict

Sugi Predict / Compounds / SCHEMBL1711085

SCHEMBL1711085

SCHEMBL1711085

COc1ccc(C2(c3ccc(OC)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2cc(OC)c(N3CCOCC3)cc2C4(C)C)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKDC P78527 9/20 0.34
▸ POLB P06746 1/20 0.33
▸ ALDH1A1 P00352 4/20 0.32
▸ MAPT P10636 4/20 0.32
▸ KDM4E B2RXH2 3/20 0.32
▸ HTT P42858 3/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ PIK3CD O00329 2/20 0.32
▸ MAPK1 P28482 2/20 0.32
▸ ALOX15 P16050 2/20 0.32
▸ XRCC6 P12956 1/20 0.32
▸ XRCC5 P13010 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ ALOX12 P18054 1/20 0.32
▸ MCL1 Q07820 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1711064 0.98 ALDH1A1 (0.36) PRKDCPOLBALDH1A1MAPTKDM4E
SCHEMBL11995965 0.88 ATM (0.33) PRKDCPOLBALDH1A1MAPTHTT
SCHEMBL1188005 0.88 ATM (0.33) PRKDCPOLBALDH1A1MAPTHTT
SCHEMBL25606356 0.87 PRKDC (0.35) PRKDCALDH1A1MAPTKDM4EMEN1
SCHEMBL29664343 0.87 HIF1A (0.34) PRKDCALDH1A1MAPTKDM4EHTT
SCHEMBL1333000 0.87 RAB9A (0.35) PRKDCALDH1A1MAPTKDM4EHTT
SCHEMBL9929184 0.87 HIF1A (0.34) PRKDCALDH1A1MAPTKDM4EHTT
SCHEMBL30914180 0.87 RAB9A (0.35) PRKDCALDH1A1MAPTKDM4EHTT
SCHEMBL1710974 0.87 RAB9A (0.35) PRKDCALDH1A1MAPTKDM4EHTT
SCHEMBL1711055 0.87 MEN1 (0.36) PRKDCALDH1A1MAPTKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1606274-B9 INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2019-01-16 — — EP claimed
EP-1606274-B1 INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2018-08-08 — — EP claimed
EP-2345647-A2 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL, INC. (US) 2011-07-20 — — EP claimed
US-7262295-B2 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL, INC. (US) 2007-08-28 — — US claimed
US-7166357-B2 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL, INC. (US) 2007-01-23 — — US claimed
US-20040185255-A1 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL LIMITED (IE) 2004-09-23 — — US claimed
US-20040185268-A1 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL LIMITED (IE) 2004-09-23 — — US claimed
EP-1606274-B9 INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2019-01-16 — — EP disclosed
EP-1606274-B1 INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2018-08-08 — — EP disclosed
EP-2345647-A2 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL, INC. (US) 2011-07-20 — — EP disclosed
US-7557208-B2 Naphthols useful for preparing indeno-fused photochromic naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2009-07-07 — — US disclosed
US-7517982-B2 Naphthols useful for preparing indeno-fused photochromic naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2009-04-14 — — US disclosed
US-20090062533-A1 NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2009-03-05 — — US disclosed
US-7262295-B2 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL, INC. (US) 2007-08-28 — — US disclosed
US-20070155964-A1 Naphthols useful for preparing indeno-fused photochromic naphthopyrans TRANSITIONS OPTICAL LIMITED (IE) 2007-07-05 — — US disclosed
US-7166357-B2 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL, INC. (US) 2007-01-23 — — US disclosed
US-20040185255-A1 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles TRANSITIONS OPTICAL LIMITED (IE) 2004-09-23 — — US disclosed
US-20040185268-A1 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL LIMITED (IE) 2004-09-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040185255-A1 Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles IPO4, NPM1, PPOX PRKDC 4372/4885POLB 1795/4885ALDH1A1 2004/4885
US-20070155964-A1 Naphthols useful for preparing indeno-fused photochromic naphthopyrans IPO5, IPO4, NQO1 PRKDC 4801/4885POLB 2101/4885ALDH1A1 1506/4885
US-20090062533-A1 NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS IPO5, IPO4, NQO1 PRKDC 4801/4885POLB 2101/4885ALDH1A1 1506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.