SCHEMBL17115462

SCHEMBL17115462

CC(C)c1ccc2c(c1)c1cc(C#N)ccc1n2-c1ccc2sc3ccc([Si](c4ccccc4)(c4ccccc4)c4ccccc4)cc3c2c1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
G6PD P11413 2/20 0.36
MIF P14174 1/20 0.31
USP14 P54578 1/20 0.31
PARP15 Q460N3 1/20 0.31
PARP10 Q53GL7 1/20 0.31
TNKS2 Q9H2K2 1/20 0.31
PARP2 Q9UGN5 1/20 0.31
PLK1 P53350 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18707097 0.89 G6PD (0.37) G6PDMIF
SCHEMBL18707066 0.88 G6PD (0.38) G6PDMIFUSP14PARP15PARP10
SCHEMBL17115469 0.86 CSNK1D (0.35) G6PD
SCHEMBL17115460 0.86 USP14 (0.33) G6PDMIFUSP14PLK1
SCHEMBL18713376 0.83 G6PD (0.35) G6PD
SCHEMBL12879643 0.82 KDM4E (0.33)
SCHEMBL18707191 0.81 RORA (0.36) G6PD
SCHEMBL17431087 0.80 G6PD (0.36) G6PDMIFUSP14
SCHEMBL17431091 0.80 G6PD (0.36) G6PDMIFUSP14
SCHEMBL17115341 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2017-04-06 US disclosed
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2017-04-06 US disclosed
WO-2015140073-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2015-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES DBF4, DDT, SLC43A3 G6PD 1474/4885MIF 1155/4885USP14 4596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.