⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712086 | 0.84 | ERN1 (0.33) | — | |
| SCHEMBL14993933 | 0.77 | CSF1R (0.33) | — | |
| SCHEMBL14993394 | 0.73 | PTGS2 (0.37) | — | |
| SCHEMBL28008826 | 0.73 | NQO2 (0.40) | — | |
| SCHEMBL2169878 | 0.73 | ALDH1A1 (0.36) | — | |
| SCHEMBL592871 | 0.71 | KCNH2 (0.38) | — | |
| SCHEMBL28052603 | 0.70 | NQO2 (0.43) | — | |
| SCHEMBL7818712 | 0.70 | HRH4 (0.35) | — | |
| SCHEMBL2289801 | 0.70 | HSD17B1 (0.32) | — | |
| SCHEMBL16681624 | 0.67 | TRPA1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822114-B2 | Tricyclic oxazolidinone antibiotic compounds | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-11-21 | — | — | US | disclosed |
| US-20160237088-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2016-08-18 | — | — | US | disclosed |
| CN-104151316-B | Tricyclazole alkanone Antibiotique composition | 埃科特莱茵药品有限公司 | 2016-06-15 | — | — | CN | disclosed |
| US-9346804-B2 | Tricyclic oxazolidinone antibiotic compounds | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-05-24 | — | — | US | disclosed |
| EP-2344495-B1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-12-31 | — | — | EP | disclosed |
| CN-104151315-A | Tricyclic oxazolidinone antibiotic compounds | ACTELION PHARMACEUTICALS LTD | 2014-11-19 | — | — | CN | disclosed |
| CN-104151316-A | Tricyclic oxazolidinone antibiotic compounds | ACTELION PHARMACEUTICALS LTD | 2014-11-19 | — | — | CN | disclosed |
| US-20140142093-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-05-22 | — | — | US | disclosed |
| US-8618092-B2 | Tricyclic oxazolidinone antibiotic compounds | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-12-31 | — | — | US | disclosed |
| US-20110195961-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-11 | — | — | US | disclosed |
| EP-2344495-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010041194-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-15 | — | — | WO | disclosed |