Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712060 | 0.85 | MTNR1A (0.40) | GFERHSD17B10L3MBTL1KDM4ENPC1 | |
| SCHEMBL3349168 | 0.85 | SERPINE1 (0.35) | GFERHSD17B10L3MBTL1DYRK1AKDM4E | |
| SCHEMBL1712460 | 0.82 | TRPA1 (0.36) | KCNH2KDM4E | |
| SCHEMBL1712457 | 0.82 | TRPA1 (0.36) | KCNH2KDM4E | |
| SCHEMBL1712711 | 0.82 | KDM4E (0.38) | GFERHSD17B10L3MBTL1KDM4ENPC1 | |
| SCHEMBL1711909 | 0.82 | KDM4E (0.38) | GFERHSD17B10L3MBTL1KDM4ENPC1 | |
| SCHEMBL1724180 | 0.81 | KCNH2 (0.43) | KCNH2 | |
| SCHEMBL1722764 | 0.78 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL1723590 | 0.78 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL1712763 | 0.78 | TRPA1 (0.33) | KCNH2KDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344495-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010041194-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-15 | — | — | WO | disclosed |