Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712711 | 1.00 | KDM4E (0.38) | KDM4ETDP1MTNR1ABCHEGFER | |
| SCHEMBL1711958 | 0.88 | MTNR1B (0.39) | KDM4ETDP1MTNR1ABCHEGFER | |
| SCHEMBL2286483 | 0.88 | MTNR1B (0.39) | KDM4ETDP1MTNR1ABCHEGFER | |
| SCHEMBL1712316 | 0.84 | MTNR1A (0.48) | KDM4EMTNR1AL3MBTL1MTNR1BPCSK9 | |
| SCHEMBL1712463 | 0.82 | KCNH2 (0.37) | KDM4EGFERHSD17B10L3MBTL1PCSK9 | |
| SCHEMBL3818896 | 0.81 | CPB2 (0.34) | KDM4ETDP1MTNR1ABCHEGFER | |
| SCHEMBL3888157 | 0.81 | ACACB (0.34) | KDM4ETDP1MTNR1ABCHEGFER | |
| SCHEMBL1712708 | 0.81 | KDM4E (0.39) | KDM4ETDP1MTNR1AMTNR1BGAA | |
| SCHEMBL1711908 | 0.81 | KDM4E (0.39) | KDM4ETDP1MTNR1AMTNR1BGAA | |
| SCHEMBL592228 | 0.81 | ADRA2A (0.42) | KDM4EMTNR1AMTNR1BGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344495-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010041194-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-15 | — | — | WO | disclosed |