Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712463 | 0.85 | KCNH2 (0.37) | GFERHSD17B10L3MBTL1KDM4ENPC1 | |
| SCHEMBL1712060 | 0.82 | MTNR1A (0.40) | SERPINE1GFERHSD17B10L3MBTL1KDM4E | |
| SCHEMBL2291901 | 0.81 | TRPA1 (0.36) | KDM4ECTSSCTSK | |
| SCHEMBL2289801 | 0.76 | HSD17B1 (0.32) | — | |
| SCHEMBL1711831 | 0.76 | ALDH1A1 (0.33) | HSD17B10KDM4ERAB9AMAPTCTSS | |
| SCHEMBL31559761 | 0.74 | DRD2 (0.38) | SERPINE1PCSK9EGFRAURKBSYK | |
| SCHEMBL24214779 | 0.71 | STK17B (0.37) | SERPINE1GFERHSD17B10L3MBTL1KDM4E | |
| SCHEMBL1711953 | 0.70 | MTNR1A (0.39) | PCSK9SYK | |
| SCHEMBL7218145 | 0.69 | ADRB1 (0.43) | SERPINE1HSD17B10KDM4ENPC1RAB9A | |
| SCHEMBL1712486 | 0.69 | MTNR1A (0.39) | SERPINE1GFERHSD17B10L3MBTL1PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010041194-A1 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-15 | — | — | WO | disclosed |