Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | P4HB | P07237 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29144717 | 0.87 | NOTUM (0.54) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL3577577 | 0.86 | NOTUM (0.57) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL29975942 | 0.85 | NOTUM (0.55) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL30848162 | 0.85 | P4HB (0.66) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL1040017 | 0.85 | NOTUM (0.55) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL18973337 | 0.85 | P4HB (0.66) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL17010776 | 0.83 | LOXL2 (0.54) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL31063216 | 0.83 | NOTUM (0.54) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL17385782 | 0.82 | NOTUM (0.53) | NOTUMP4HBMAPTALDH1A1HSD17B10 | |
| SCHEMBL17385775 | 0.82 | NPC1 (0.56) | NOTUMP4HBMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9400280-B2 | Piperidine derivatives and methods of treating hepatitis B infections | NOVIRA THERAPEUTICS, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9400280-B2 | Piperidine derivatives and methods of treating hepatitis B infections | NOVIRA THERAPEUTICS, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150274652-A1 | PIPERIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | NOVIRA THERAPEUTICS, INC. | 2015-10-01 | — | — | US | disclosed |
| US-20150274652-A1 | PIPERIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | NOVIRA THERAPEUTICS, INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274652-A1 | PIPERIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | HAVCR2, HAMP, EBNA1BP2 | NOTUM 1883/4885P4HB 846/4885MAPT 4424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.