Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | P4HB | P07237 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526088 | 0.87 | LOXL2 (0.54) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL3577577 | 0.86 | NOTUM (0.57) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL1040017 | 0.85 | NOTUM (0.55) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL18973337 | 0.85 | P4HB (0.66) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL30848162 | 0.85 | P4HB (0.66) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL29975942 | 0.85 | NOTUM (0.55) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL15862210 | 0.84 | LOXL2 (0.59) | LOXL2MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL12942923 | 0.84 | CA1 (0.53) | MAPTALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL17124875 | 0.83 | NOTUM (0.58) | LOXL2NOTUMP4HBMAPTALDH1A1 | |
| SCHEMBL31063216 | 0.83 | NOTUM (0.54) | LOXL2NOTUMP4HBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104703-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3104703-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2020-11-18 | — | — | EP | disclosed |
| US-9944643-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-04-17 | — | — | US | disclosed |
| US-9944643-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160376272-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160376272-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-29 | — | — | US | disclosed |
| EP-3104703-A1 | FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123093-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-08-20 | — | — | WO | disclosed |
| WO-2015123093-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376272-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | LOXL2 298/4885NOTUM 757/4885P4HB 1912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.