Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 9/20 | 0.44 |
| ▸ | RARB | P10826 | 9/20 | 0.44 |
| ▸ | RARG | P13631 | 9/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | RPA1 | P27694 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XPA | P23025 | 1/20 | 0.37 |
| ▸ | ADH5 | P11766 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17125414 | 0.92 | KDM4E (0.52) | RARARARBRARGSIRT5MEN1 | |
| SCHEMBL12872234 | 0.90 | RPA1 (0.49) | RARARARBRARGMEN1KMT2A | |
| SCHEMBL12872236 | 0.79 | KDM4E (0.48) | MEN1KMT2APOLBKDM4EAPEX1 | |
| SCHEMBL29070695 | 0.73 | ADH5 (0.47) | RARGMEN1KMT2APOLBKDM4E | |
| SCHEMBL27695766 | 0.72 | HTT (0.52) | MEN1KMT2APOLBKDM4EAPEX1 | |
| SCHEMBL182283 | 0.70 | KCNJ1 (0.45) | RARGMEN1KMT2APOLBKDM4E | |
| SCHEMBL7141426 | 0.69 | CYP19A1 (0.40) | MAPT | |
| SCHEMBL2708392 | 0.69 | NPC1 (0.47) | MEN1KMT2AKDM4EMAPTADH5 | |
| SCHEMBL2710612 | 0.68 | KDM4E (0.58) | MEN1KMT2APOLBKDM4EMAPT | |
| SCHEMBL2712136 | 0.68 | ALDH1A1 (0.47) | MEN1KMT2APOLBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | PTC THERAPEUTICS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | UPF1, RNMT, VHL | RARA 3067/4885RARB 2833/4885RARG 3389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.