Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PKLR | P30613 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712641 | 0.89 | MAPT (0.54) | ALDH1A1LMNASMN1; SMN2HTTPKM | |
| SCHEMBL1712968 | 0.86 | MAPT (0.53) | ALDH1A1LMNASMN1; SMN2HTTPKM | |
| SCHEMBL1713056 | 0.80 | MAPK1 (0.67) | ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL1713223 | 0.78 | MAPK1 (0.63) | ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL7829590 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7832350 | 0.74 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5243063 | 0.74 | ALDH1A1 (0.74) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL4094978 | 0.73 | LMNA (0.67) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL1713250 | 0.73 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL29873927 | 0.73 | ALDH1A1 (0.73) | ALDH1A1LMNASMN1; SMN2HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | claimed |
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |