Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712641 | 0.97 | MAPT (0.54) | MAPTLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL1712558 | 0.86 | ALDH1A1 (0.67) | LMNAPKMALDH1A1PKLRGAA | |
| SCHEMBL1713223 | 0.82 | MAPK1 (0.63) | MAPTKMT2AALDH1A1MEN1GAA | |
| SCHEMBL1713470 | 0.82 | MAPT (0.66) | MAPTLMNAKMT2AMEN1GAA | |
| SCHEMBL1713497 | 0.80 | MAPT (0.64) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL1713056 | 0.80 | MAPK1 (0.67) | MAPTKMT2AALDH1A1MEN1GAA | |
| SCHEMBL4094978 | 0.74 | LMNA (0.67) | MAPTLMNAALDH1A1GAAHTT | |
| SCHEMBL1712628 | 0.74 | FAAH (0.51) | MAPTLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL1712636 | 0.72 | LMNA (0.67) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5245498 | 0.71 | MAPT (1.00) | MAPTLMNAKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | claimed |