Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18999709 | 0.81 | F2RL1 (0.37) | PIP4K2CGPR55F2RL1 | |
| SCHEMBL27302027 | 0.77 | GPR55 (0.38) | PIP4K2CGPR55CNR2F2RL1 | |
| SCHEMBL23809439 | 0.73 | ACE2 (0.49) | ACE2F2RL1 | |
| SCHEMBL13184301 | 0.71 | KMT2A (0.34) | — | |
| SCHEMBL2381219 | 0.68 | F2RL1 (0.34) | F2RL1 | |
| SCHEMBL30954328 | 0.68 | LMNA (0.37) | F2RL1 | |
| SCHEMBL23809437 | 0.67 | ACE2 (0.49) | ACE2F2RL1 | |
| SCHEMBL19297217 | 0.67 | GPR55 (0.36) | ACE2GPR55CNR2 | |
| SCHEMBL21515787 | 0.66 | GABRA1 (0.30) | — | |
| SCHEMBL19007323 | 0.66 | PTGS2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122353-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2020-10-28 | — | — | EP | disclosed |
| WO-2015148854-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-10-01 | — | — | WO | disclosed |