SCHEMBL1713010

SCHEMBL1713010

O=C(OC#Cc1ccccc1)c1cccc(C(=O)OC#Cc2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.45
ATM Q13315 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
ALDH1A1 P00352 3/20 0.42
NPSR1 Q6W5P4 3/20 0.42
HSP90AA1 P07900 2/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 2/20 0.42
F2 P00734 1/20 0.42
LMNA P02545 1/20 0.42
MEN1 O00255 1/20 0.42
MITF O75030 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PTPN11 Q06124 1/20 0.40
FFAR1 O14842 1/20 0.40
TSHR P16473 1/20 0.39
APP P05067 1/20 0.39
RAB9A P51151 1/20 0.39
S1PR2 O95136 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2256472 0.90 LMNA (0.52) TDP1ALDH1A1NPSR1MAPTF2
SCHEMBL1713040 0.86 LMNA (0.46) TDP1L3MBTL1ALDH1A1NPSR1HSP90AA1
SCHEMBL2745851 0.81 TSHR (0.46) TDP1F2LMNAPTPN11FFAR1
SCHEMBL15611389 0.80 TSHR (0.50) TDP1F2LMNAPTPN11TSHR
SCHEMBL38695 0.79 NPC1 (0.47) TDP1L3MBTL1ALDH1A1NPSR1LMNA
SCHEMBL28358478 0.78 ALDH1A1 (0.54) TDP1ATML3MBTL1ALDH1A1MAPT
SCHEMBL1926585 0.75 TSHR (0.60) TDP1L3MBTL1ALDH1A1MAPTLMNA
SCHEMBL3130209 0.75 ALOX5 (0.41) TDP1ATML3MBTL1ALDH1A1MAPT
SCHEMBL23880583 0.75 APP (0.44) L3MBTL1ALDH1A1NPSR1HSP90AA1F2
SCHEMBL9364505 0.75 NPSR1 (0.46) L3MBTL1ALDH1A1NPSR1HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2344568-B1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2017-12-20 EP claimed
US-8492507-B2 Acetylenic polyamide NEXAM CHEMICAL AB (SE) 2013-07-23 US claimed
US-20110190469-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2011-08-04 US claimed
EP-2344568-A1 ACETYLENIC POLYAMIDE Nexam Chemical AB (SE) 2011-07-20 EP claimed
WO-2010036170-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2010-04-01 WO claimed
WO-2010030216-A1 ACETYLENIC POLY(ALKYLENE PHTHALATE) NEXAM CHEMICAL AB (SE) 2010-03-18 WO claimed
CN-115197565-B Semi-crystalline polyamide composition based on short diamines with high glass transition temperature, process for its production and use thereof 阿科玛法国公司 2024-10-11 CN disclosed
CN-115197565-A Semi-crystalline polyamide composition based on short diamines with high glass transition temperature, method for the production thereof and use thereof 阿科玛法国公司 2022-10-18 CN disclosed
CN-110446740-B Semi-crystalline polyamide compositions based on short diamines with high glass transition temperature, method for the production thereof and use thereof 阿科玛法国公司 2022-07-12 CN disclosed
CN-110431169-B Semi-crystalline polyamide composition having a high glass transition temperature and a high melting temperature, method for preparing same and use thereof 阿科玛法国公司 2022-05-17 CN disclosed
EP-2344568-B1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2017-12-20 EP disclosed
US-8492507-B2 Acetylenic polyamide NEXAM CHEMICAL AB (SE) 2013-07-23 US disclosed
US-20110190469-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2011-08-04 US disclosed
EP-2344568-A1 ACETYLENIC POLYAMIDE Nexam Chemical AB (SE) 2011-07-20 EP disclosed
WO-2010036175-A1 MOULDED ARTICLE OBTAINED FROM ACETYLENIC POLYAMIDE NEXAM CHEMICALS (SE) 2010-04-01 WO disclosed
WO-2010036170-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2010-04-01 WO disclosed
WO-2010030216-A1 ACETYLENIC POLY(ALKYLENE PHTHALATE) NEXAM CHEMICAL AB (SE) 2010-03-18 WO disclosed